10 best antiviruses to secure Office 365 [Virus Protection]

by Milan Stanojevic
Milan Stanojevic
Milan Stanojevic
Windows & Software Expert
Milan has been enthusiastic about PCs ever since his childhood days, and this led him to take interest in all PC-related technologies. Before joining WindowsReport, he worked as... read more
Affiliate Disclosure
  • An antivirus is needed to protect your Office 365 even if it already has built-in security options.
  • If you want a free solution to protect you from scams, and identity theft, you can try Avira or Avast.
  • A great choice for your business, Bitdefender includes the adaptive GravityZone tool that can detect and prevent cyber-attacks. 
  • Kaspersky, like other apps from our guide, will scan your Office 365 emails, which makes it one of the best antiviruses with complete protection.
antivirus for office 365
ESET Antivirus comes with all the security tools that you may ever need to protect your data and privacy, including:

  • Anti-theft support
  • Webcam protection
  • Intuitive setup and UI
  • Multi-platform support
  • Banking-level encryption
  • Low system requirements
  • Advanced anti-malware protection

An antivirus program needs to be fast, efficient, and cost-effective, and this one has them all.

Office 365 comes with antimalware and antispam protection as Microsoft introduced the world to the Advanced Threat Protection feature for Office 365.

Some of the benefits that came with this new solution include antimalware protection, real-time protection against malicious links, as well as rich reporting and tracking capabilities for URLs.

If you’re an Office 365 user with mailboxes hosted on Microsoft Exchange Online, then your email messages, both incoming and outgoing are automatically protected from spam and malware.

Office 365 has a built-in antispam filtering feature that protects inbound and outbound emails from malicious software and spam. This technology is enabled by default.

However, if you still feel the need for another antivirus for Office 365, there are a myriad of options you can choose from to suit your needs.


What is the best antivirus for Office 365?

ESET Internet Security

ESET Internet Security is the best choice one can make, to secure all online activities and as well the Office 365 account.

It is a modern multiplatform solution, that can be used to secure all your devices with a single license. No matter if you run on a Mac, Windows, Android or Linux.

The Anti-Phishing tool protects your privacy and assets against attempts by fraudulent websites to acquire sensitive information such as usernames, passwords, or banking details.

This is a great plus because it protects you from fake news from seemingly reputable sources, and homoglyph attacks (replacing characters in links with ones that look similar but are actually different).

ESET Internet Security

ESET Internet Security

Protect your Office 365 with a comprehensive security and online privacy solution from ESET.

Free trialVisit website

Avast Free Antivirus

Avast Free Antivirus is a solution to protects your computer and Office 365 account, against viruses, malware, and your home network against intruders.

This antivirus protects your devices against havoc-wreaking ransomware so you don’t become the victim of digital extortion.

The Game Mode now called Do Not Disturb Mode, will blocks distracting popups whether you’re gaming, watching movies, or presenting a PowerPoint document in full screen.

Avast Free Antivirus

Avast Free Antivirus

Protect your Office 365 with a free solution against viruses, malware and network intruders.

Free downloadVisit website


avira prime

Avira antivirus is another freeware security solution that will protect you from scams, identity theft, and financial loss.

The free VPN included will assure you privacy while surfing online. Moreover, it will block all online threats like malware, ransomware, or spyware.

Your Office 365 mailbox as well as you social network accounts will be protected for phishing with the Anti-Scam tool.



Check this amazing free antivirus with great Anti-Scam solution for your Office 365 mailbox.


Bitdefender is the leading antivirus for Office 365, which protects against any sophisticated threats. It is powerful, simple, and ideal for business use, plus it has consistently ranked first in independent tests.

The GravityZone tool is adaptive, layered endpoint security designed for cloud and virtualization, that protects from advanced targeted attacks.

The GravityZone feature executes its protective functions through its monitoring and revolutionary hypervisor introspection architecture.

This endpoint protection against cyber threats can detect advanced persistent threats, and offers protection from ransomware and defeats exploits, and zero-day attacks.

You’ll find it easy to install and monitor remotely from a single, powerful cloud console, plus it is also very cost-effective.



Use an antivirus compatible with Office 365, with VPN included and great customer support.

Check priceVisit website

Emsisoft Anti-Malware

Emsisoft Anti-Malware is the perfect security extra-layer for your PC or laptop. It works perfectly on any hardware configuration and supports both x32 and x64 platforms.

This tool has a dual-engine scanner that keeps safe all your files and reacts instantly when a file has an unknown modification or source.

Its anti-malware and anti-ransomware security will keep you safe while surfing. Another great feature is its Behaviour Blocker. This tool detects even the not-yet-known threats and unknown signatures.

Emsisoft Anti-Malware is a great tool that comes at a great price, around $20, which is a better price than other popular antiviruses.

It also has great rankings in many independent tests. You can find more information and download it in the link below.

Emsisoft Anti-Malware

Emsisoft Anti-Malware

With 4 protection layers to block online threats, Emsisoft is a great choice to protect your Office 365.

Check priceVisit website


Panda’s Cloud Protection is an antivirus for Office 365 that comes with endpoint cloud-based antimalware and firewall protection, plus email traffic filtering.

It also guarantees the highest protection for endpoints and emails, using its collective intelligence tool that ensures files are constantly and automatically updated.

The firewall is personal or managed, plus it has cloud-based antispam filtering.

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It is easy to use, minimal maintenance costs, and it optimizes the consumption of bandwidth and endpoint resources while avoiding inoperative traffic and minimizing server load.

Features include a hosted web console, profile-based protection, flexible installation, detailed email reports, vulnerability and threat assessment, plus management delegation among others.

For email protection, you get hosted email spam filtering, guaranteed availability, quarantine management, and unlimited domain alias, plus so much more.



Keep you Office 365 protected with real-time monitoring and personal firewall from Panda.

Check priceVisit website

AVG Antivirus

Another solid antivirus software that you might want to consider is AVG Antivirus. This antivirus offers protection against standard threats including viruses, spyware, and ransomware.

In addition, this tool will block unsafe links, downloads, and malicious email attachments. It also supports real-time security updates, and it can even scan your PC for performance problems.

AVG Antivirus is available in two versions, and while the Free version has all the aforementioned features, the Internet Security version offers complete system protection for your PC.

This version offers additional features such as an extra layer of ransomware protection and webcam protection.

Another great feature available in this version is Enhanced Firewall, so you can easily monitor your online traffic and choose which applications have access to the Internet.

AVG Internet Security also has anti-phishing protection so it can easily detect malicious websites and prevent them from stealing your data.

It’s worth mentioning that this tool is available on the Android platform as well, so if you need to protect your Android device, you might want to consider this tool.

Overall, AVG Antivirus offers solid features, and if you’re looking for basic protection, you might want to try the Free version.

On the other hand, if you need full system protection along with some advanced features, you might want to consider getting the Internet Security version.

AVG Antivirus

AVG Antivirus

AVG will block unsafe links, downloads, & email attachments assuring great protection for your Office 365.

Check priceVisit website


With Kaspersky Security antivirus for Office 365, you are able to protect your mailboxes managed through this cloud app.

Your email messages are also scanned for viruses and other malware threats that may be transmitted via email, including spam and phishing.

Kaspersky Security for Microsoft Office 365 features antivirus, antiphishing and antispam protection, and attachment filtering.

It can scan incoming and outgoing mail for malware, filter spam from user mailboxes, scan email messages for phishing and malicious links, and filter attachments in email messages.

Additionally, it will move messages to backup to prevent data loss risks, notify the system admin about messages with malicious objects or filtered attachments, and display app activity statistics.



Use a great antivirus for Office 365, that prevents crypto mining malware infections and block ransomware.

Free trialVisit website

Norton by Symantec

This antivirus for Office 365 protects your sensitive data from loss or theft, protects user accounts, prevents threats in your emails, and blocks advanced attacks.

Besides, it allows you to respond quickly to security incidents with comprehensive log data.

There is a VPN included to protect your privacy while surfing online and also multiple layers of protection for your devices, game accounts, and digital assets.

Norton by Symantec

With a continuous malware scanning and power eraser (blocks suspicious files), your Office 365 is safe.

Check price Visit website


BullGuard antivirus for Office 365 incorporates innovative multi-layered defenses that block all forms of malicious threats, ensuring optimal performance.

Features include a vulnerability scanner to detect outdated software that is easily exploited by hackers and a free powerful backup to keep your files safe in case of a system crash or computer loss.

Other tools include behavioral-based detection, antispam filters, a feature that stops unwanted apps from hijacking your browser, and automatic PC tune-up.

With the traditional signature-based protection combined with behavioral-based protection, BullGuard protects against known and new malware outbreaks, with industry-leading detection rates.

It is simple to navigate with an effective, user-friendly design and easy to use dashboard interface with clearly marked features and actions.

Get Bullguard

Furthermore, to make sure your Outlook mailbox is safe, you can use any of these best email-scanning software to remove malware.

Are you ready to secure your business with any of these best antiviruses for Office 365? Share your favorite and why by leaving a comment in the section below.

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