FIX: Sysprep Fatal Error, Could not load MSESysprep.dll

Tashreef Shareef
by Tashreef Shareef
Windows & Software Expert
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Sysprep Fatal Error, Could not load MSESysprep.dll
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While running the System Preparation tool you may encounter several errors. One such error is Sysprep Fatal Error, Could not load MSESysprep.dll.

This error is common in an older version of Windows and occurs due to a missing .dll file in the installation directory. One Windows user reported a similar error in the Microsoft community:

Trying to run sysprep – fatal error because MSE was once installed
I have a W7 Prof 64 bit machine I am trying to Sysprep.
I had MSE installed previously and uninstalled it. And I am aware of the REARM issue and I dont believe it to be the cause.

If you are also troubled by this error, here are a couple of troubleshooting tips to help you resolve Sysprep Fatal Error, Could not load MSESysprep.dll error in Windows.

How can I fix Sysprep dll errors on my Windows PC?

1. Delete an invalid entry from the registry

Sysprep Fatal Error, Could not load MSESysprep.dll

  1. Press Windows Key + R to open Run.
  2. Type regedit and click OK to open the Registry Editor.
  3. On the Registry Editor, click on File and Export. Give the file a name and save it in a safe location. This way you can restore the registry files if anything goes wrong.
  4. In the Registry Editor, navigate to the following location:
    HKLMsoftwareMicrosoftWindowsCurrentVersionSetupSysprepCleanup
  5. Right-click on Cleanup Key.
  6. Select Permissions.
  7. In the Permission window, select Administrators.
    Sysprep Fatal Error, Could not load MSESysprep.dll
  8. Under Permissions for Administrators, check Allow box for Full Control.
  9. Click Apply and OK to save the changes.
  10. Select the CleanUp key again.
  11. From the right pane, delete the following value:
    2D153B43-11B4-461F-AA43-832B2C8B8872
  12. Right-click on the value and select Delete.
  13. Close the registry editor.

If you can’t edit your Windows 10‘s registry, read this handy guide and find the quickest solutions to the issue.

Run a third-party DLL fixer

There are plenty of third-party programs out there that promise to fix or replace missing or broken DLLs, and most of them stay true to their word. However, if you are to choose just one, then there’s no way you can go wrong with Restoro.

How to use Restoro to fix missing or broken DLLs

  1. Download here Restoro and install it on your Windows 10 PC
  2. Let Restoro perform a full system scan
  3. When the scan is finished, press Clean Now
    • This is when you will have to activate your license key
    • Before the repair process starts, Restoro will create a restore point of your system in case things go wrong
  4. Restoro will now proceed to fix your DLL-related issue.

Note: While Restoro can be downloaded for free, it has limited functionality until you activate it. That being the case, if you want the full benefit of a great PC repair and optimization tool, you should purchase the full license.


Delete Panther folder

Sysprep Fatal Error, Could not load MSESysprep.dll

  1. Open File Explorer.
  2. Navigate to the following location:
    C:WindowsSystem32sysprep 
  3. Right-click on the Pather folder.
  4. You can delete the folder or simply rename it.
  5. Run the System Preparation tool again and it should run successfully without errors.

File Explorer is slow in Windows 10? Follow the simple steps from this guide and get it running fast again with ease.


2. Use Revo Uninstaller

Sysprep Fatal Error, Could not load MSESysprep.dll

  1. Download and install Revo Uninstaller.
  2. Launch Revo Uninstaller.
  3. Under Applications, check for the Microsoft Security Essentials application.
  4. Select it and click Uninstall.
  5. Next, run the Ccleaner app and clean any leftover junk files related to MSE.
  6. Once done, restart the computer and run the System Preparation tool.

The Sysprep Fatal Error, Could not load MSESysprep.dll seems to occur due to incomplete uninstallation of Microsoft Security Essentials. By following the steps in this article you can fix the error and continue with the Sysprep process.

If you have any other questions or suggestions, feel free to leave them in the comments section below.

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