FIX: Sysprep Fatal Error, Could not load MSESysprep.dll

Tashreef Shareef
by Tashreef Shareef
Windows & Software Expert
Last update:
Affiliate Disclosure

  • If you encounter Sysprep Fatal Error, Could not load MSESysprep.dll while running the system preparation tool, don't panic, because there's a fix for it!
  • You can fix this scary error with some registry tweaks, check out this guide to see the full steps.
  • Another great solution is to use a specialized repair tool to fix the operating system errors, which you can find below.
  • Also keep reading to find out which folder you have to delete in order to fix this error for good.
How to fix the Sysprep Fatal Error, Could not load MSESysprep.dll
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While running the System Preparation tool you may encounter several errors. One such error is Sysprep Fatal Error, Could not load MSESysprep.dll.

This error is common in an older version of Windows and occurs due to a missing .dll file in the installation directory. One Windows user reported a similar error in the Microsoft community:

Trying to run sysprep – fatal error because MSE was once installed
I have a W7 Prof 64 bit machine I am trying to Sysprep.
I had MSE installed previously and uninstalled it. And I am aware of the REARM issue and I dont believe it to be the cause.

If you are also troubled by this error, here are a couple of troubleshooting tips to help you resolve Sysprep Fatal Error, Could not load MSESysprep.dll error in Windows.


How can I fix the Sysprep dll errors on my Windows PC?

1. Delete an invalid entry from the registry

  1. Press Windows Key + R to open Run.
  2. Type regedit and click OK to open the Registry Editor.
  3. On the Registry Editor, click on File and Export. Give the file a name and save it in a safe location. This way you can restore the registry files if anything goes wrong.
  4. In the Registry Editor, navigate to the following location:
    HKLM\software\Microsoft\Windows\Current\Version\Setup\Sysprep\Cleanup
  5. Right-click on Cleanup Key.
  6. Select Permissions.
  7. In the Permission window, select Administrators.
    Sysprep Fatal Error, Could not load MSESysprep.dll
  8. Under Permissions for Administrators, check Allow box for Full Control.
  9. Click Apply and OK to save the changes.
  10. Select the CleanUp key again.
  11. From the right pane, delete the following value:
    2D153B43-11B4-461F-AA43-832B2C8B8872
  12. Right-click on the value and select Delete.
  13. Close the registry editor.

If you can’t edit your Windows 10s registry, then you should use a proper repair tool for this. We strongly recommend you to use Restoro find the quickest solutions to the issue.

Restoro repair
Restoro is a reliable third-party DLL fixer which uses a built-in automated system and an online library full of functional DLLs to replace and repair any files that might be corrupted or damaged on your PC. All you need to do to resolve your PC’s problems is to launch it, and simply follow the on-screen instructions to start the process, as everything else is covered by the software’s automated processes. This is how you can fix registry errors using Restoro:
  1. Download and install Restoro.
  2. Launch the software.
  3. Wait for it to scan your PC for any stability issues and possible malware.
  4. Press Start Repair.
  5. Restart your PC for all the changes to take effect.
After this process is completed your PC will be as good as new, and you will no longer have to deal with BSoD errors, slow response times, or other similar issues. Get Restoro Disclaimer: This program needs to be upgraded from the free version in order to perform some specific actions.

2. Use IObit Uninstaller

  1. Download and install IObit Uninstaller.
  2. Launch IObit Uninstaller.
  3. Under Applications, check for the Microsoft Security Essentials application.
  4. Select it, and click Uninstall.
  5. Next, run the Ccleaner app, and clean any leftover junk files related to MSE.
  6. Once done, restart your PC and run the System Preparation tool.
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3. Delete the Panther folder

Sysprep Fatal Error, Could not load MSESysprep.dll
  1. Open File Explorer.
  2. Navigate to the following location:
    C:\Windows\System32\sysprep 
  3. Right-click on the Pather folder.
  4. You can delete the folder or simply rename it.
  5. Run the System Preparation tool again, and it should run successfully without errors.

File Explorer is slow in Windows 10? Follow the simple steps from this guide and get it running fast again with ease.


The Sysprep Fatal Error, Could not load MSESysprep.dll seems to occur due to incomplete uninstallation of Microsoft Security Essentials.

By following the steps in this article you can fix the error and continue with the Sysprep process.

If you have any other questions or suggestions, feel free to leave them in the comments section below.

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