5+ best antivirus software for USB flash drives [2022 Guide]

by Radu Tyrsina
Radu Tyrsina
Radu Tyrsina
CEO & Founder
Radu Tyrsina has been a Windows fan ever since he got his first PC, a Pentium III (a monster at that time). For most of the kids of... read more
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  • Finding the best antivirus for USB flash drives will keep you safe from infecting with malware from external storage sources.
  • Even a free solution, like Avira or Avast, represents a comprehensive cybersecurity tool.
  • A great USB antivirus should disable autorun-related threats before they can access your PC.
  • Our top pick from ESET and Bitdefender will protect your computer and media storage against all types of malware, including viruses, ransomware, worms, and spyware.
Antivirus software for USB flash drive
ESET Antivirus comes with all the security tools that you may ever need to protect your data and privacy, including:

  • Anti-theft support
  • Webcam protection
  • Intuitive setup and UI
  • Multi-platform support
  • Banking-level encryption
  • Low system requirements
  • Advanced anti-malware protection

An antivirus program needs to be fast, efficient, and cost-effective, and this one has them all.

USB flash drives are useful storage devices that are not expensive at all. You can use a USB flash drive to keep emergency information and current project files always with you.

You can use them to carry your browser and program settings with you and use them on any PC featuring a USB port. Flash drives are also useful for troubleshooting and repairing all kinds of issues.

You can also use a flash drive to make Windows run faster and run a different operating system without changing your hard drive.

USB flash drive makes life much easier. But wait for a second! They can also pose a threat to your computer’s security.

If your USB flash drive is infected with malware, it can cause not only the loss of your data but also spread malware to all the computers it gets plugged into.

Today, the usage of USB drives has increased a lot because of their portability. Infected USB flash drives can transfer personal or financial information to the intruder or even delete important data.

Prevention is always better than cure. For this reason, we’re going to the best antivirus software to protect your computer against infected USB flash drives.

They can be used whenever you’re looking for:

  • USB antivirus – USB flash drives are supposed to be virus-free, so make sure things remain the same even after months of usage
  • Bootable antivirus USB – Bootable antivirus programs let you create a special flash drive from a working PC and later use it to scan the hard drive even without starting Windows
  • USB antivirus scanner – When your wish is to scan your USB flash drives for any malware, these great antivirus solutions with USB scanner can help you out
  • Run antivirus from USB – Booting your PC from a USB drive containing an antivirus often does wonders, so don’t hesitate to pick one of our previously mentioned antivirus solutions

What’s the best antivirus software for USB flash drives?

ESET Antivirus

best antivirus for windows 7

ESET Antivirus is a fast and light security solution, vital for gamers and everyday users that don’t want any malware infection or a PC running slow.

It will protect your computer and USB flash drivers against all types of malware, including viruses, ransomware, worms and spyware.

Moreover, fi you like playing games, you can rest assured that no system updates or annoying pop-ups will be displayed while you play games or run a program in full-screen mode.

The device control technology allows you to prevent unauthorized copying of your private data to an external device.

Additionally, it allows you to block storage media, such as CDs, DVDs, USB sticks, and disk storage devices. You can also block devices connecting via Bluetooth, FireWire and serial/parallel ports.

ESET Antivirus

ESET Antivirus

Use a legendary antivirus, with multiple protection features that allows you to scan and block infected USB devices.

Free trialVisit website


Avira is another great choice if you are looking for a free security solution for your computer. It is a comprehensive, professional-level cybersecurity that is free for home use.

The antivirus protection will block all online threats, such as malicious websites, ransomware and any spyware that you can get while surfing the web.

It will also block any infected USB flash drives or other media storage connected to your computer. So, you don’t have to worry when using a USB with documents from another computer.



Scan your USB devices with a great free antivirus solution. Don’t worry for infected USB, they will be blocked.


Error 268d3

Autorun-based malware is one of the world’s most vicious e-threats. Introduced back in the Windows XP era, the Autorun feature has rapidly become the main infection tool for many cybercriminals.

The USB Immunizer software is Bitdefender’s response to this enormous and steadily growing problem. The software disables autorun-related threats before they can access your PC.

Once the program is installed, it will regularly check for newly inserted USB storage devices, immunizing them on the spot.

If you plug in an infected USB drive, your computer will not auto-execute the malware code stored on it. The Computer Immunization setting disables the registry entry related to Autorun.

In this manner, a removable storage device (except for CD & DVD ROM media) won’t be able to execute any malware upon mounting. It also immunizes each system partition with a specially-crafted autorun.inf file.

The USB immunizer is available in English, Spanish, Portuguese, Arabic, Thai, Vietnamese, Polish, Farsi, German, French, and Romanian.

The software reads the current location of the user in the Region and Language settings and automatically loads the appropriate language file.

Do note that the Bitdefender antivirus for flash drives is not a standalone program. It comes incorporated in the complete antivirus package.



Bitdefender is a big name in the antivirus business, so it’s the best choice for protecting USB flash drives

Check priceVisit website


get Panda USB Vaccine

The Panda includes the USB Vaccine, which is a great utility that disables the Autorun feature from USB drives, preventing malware from infecting your PC.

When this software is applied on the USB drive, it will permanently block the autorun.inf file and it will prevent it from being read, created, deleted, and modified.

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In this manner, Windows won’t be able to automatically execute any malicious file that might be stored on the flash drive. You can then use your USB flash drive in a normal way to copy, move, or delete files.

The software works great on FAT and FAT32 USB drives. As a quick reminder, the USB drives that have already been vaccinated can only be reversed to a previous state through formatting.

Users can also operate the software via the command line. No less important, Panda USB Vaccine it’s part of the complete Panda antivirus package.

Therefore, we can only recommend downloading Panda antivirus which will double your USB-health security.



Stop worrying about USB flash drive infections when you use this antivirus. Claim the best Panda deal right away!

Check priceVisit website

ClevX DriveSecurity

get ClevX DriveSecurity

DriveSecurity is a powerful antivirus solution dedicated to users who often transfer various files, such as pictures, music, videos via USB drives.

The tool nips malware in the bud, removing it before you transfer any infected files to your drive. In this manner, your USB flash drive is always malware-free.

DriveSecurity detects a wide range of threats, including viruses, rootkits, worms, and spyware.

ClevX DriveSecurity USB antivirus key features:

  • Works with any USB drive
  • Automatic scanning and virus removal
  • No host installation required
  • Encrypted secure drives companion

Download ClevX DriveSecurity now

USB Disk Security

try out USB Disk Security

This program detects any virus before it infects your memory stick and then your whole system. By their very own nature, flash drives are prone to infections.

Oftentimes, users connect them to various computers and this increases the high risk of getting infected.

Once you install it, the USB Disk Security will automatically run whenever a flash drive is inserted into your machine, checking for infections.

USB Disk Security also features a USB scan tool and various repair options. Unfortunately, these features are not available in the trial version.

USB Disk Security delivers a high level of protection against any malicious programs.

It protects your PC against data theft and accidental disclosure of confidential information, preventing unauthorized persons from stealing your data.

The tool is also compatible with other antivirus software, and won’t slow down your computer. When you minimize it, the USB Disk Security will run silently in the task tray.

The limitations of the trial version are a bit disappointing. The program is very efficient at scanning inserted flash drives and we really think it’s worth checking it out.

Download USB Disk Security now

Avast Free Antivirus

Avast Free Antivirus is another great tool to use in order to protect your computer against viruses and malware, and also to keep your home network safe against intruders.

If features a Do Not Disturb Mode that can block distracting popups whether you’re gaming, watching movies, or presenting in full screen.

You can scan all your computer-connected media storage, including USB flash driver, HDD, SDD, or any other type of PC storage.

This antivirus has a free version that will check your applications for malware and also keep an eye on their behavior to make sure they don’t suddenly go rogue.

Get Avast Free Antivirus


If you are looking for a  trialware antivirus that works fast and has a great protection rating, then Bullguard is the best option for you.

In addition to file scanning, Bullguard also brings a spam filter to your local email client as well as the traffic scanning feature that will work while you are browsing the web.

Let’s quickly look at its key features:

  • Protection from web-based attacks
  • Highly focused on privacy
  • Integrated Vulnerability scanner and Firewall
  • Machine Learning powered detection algorithms to identify even the most advanced threats
  • Triple-layer next-generation antimalware protection

Get Bullguard

This list features the best antivirus solutions for USB drives. All these programs are lightweight, automatic, and compatible with fully-fledged antivirus software.

Additionally, you can add extra protection to your devices with any of these best firewall devices to protect your home network.

If you have any suggestions that we should include in our list, please leave us a comment below.

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Frequently Asked Questions

  • Hackers, exploiters, and eavesdroppers have found new ways to use USB flash drives to infect PCs. That’s why using the best antivirus software tools for USB is mandatory.

  • If looking for the best USB antivirus, we can only suggest you try out these great antiviruses with USB scanner.

  • Windows Defender is indeed a decent choice. However, it offers basic security features, thus, we recommend you to use any of these best antiviruses for Windows 10.

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