4 best antivirus software for USB flash drives [2020 Guide]

Radu Tyrsina
by Radu Tyrsina
Founder & Editor-in-Chief
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  • Finding the best antivirus software for USB flash drives is about to get so much easier today.
  • We recommend making an informed choice from Bitdefender USB Immunizer, Panda USB Vaccine, and the other tools mentioned below.
  • Looking for help is natural with so many challenges to face, so visit this USB flash drive section.
  • For more guides, check out our Antivirus Software Hub too. You won’t walk away disappointed.
Antivirus software for USB flash drive

USB flash drives are useful storage devices that are not expensive at all. You can use a USB flash drive to keep emergency information and current project files always with you.

You can also use them to carry your browser and program settings with you and use them on any computer featuring a USB port.

Flash drives are also useful for troubleshooting and repairing all kinds of issues.

You can also use a flash drive to make Windows run faster and run a different operating system without changing your hard drive.

Want to dual boot Windows 10 and another OS? Check out this guide to learn how you can properly do it.

USB flash drive makes life much easier. But wait for a second! They can also pose a threat to your computer’s security.

If your USB flash drive is infected with malware, it can cause not only the loss of your data but also spread malware to all the computers it gets plugged into.

Today, the usage of USB drives has increased a lot because of their portability. Infected USB flash drives can transfer personal or financial information to the intruder or even delete important data.

Prevention is always better than cure. For this reason, we’re going to the best tools to protect your computer against infected USB flash drives.

We strongly recommend you use these antivirus tools.

What's the best antivirus software for USB flash drives?

get Bitdefender USB Immunizer

Autorun-based malware is one of the world’s most vicious e-threats. Introduced back in the Windows XP era, the Autorun feature has rapidly become the main infection tool for many cybercriminals.

The USB Immunizer software is Bitdefender’s response to this enormous and steadily growing problem. The software disables autorun-related threats before they can access your PC.

Once the program is installed, it will regularly check for newly inserted USB storage devices, immunizing them on the spot.

If you plug in an infected USB drive, your computer will not auto-execute the malware code stored on it. The Computer Immunization setting disables the registry entry related to Autorun.

In this manner, a removable storage device (except for CD & DVD ROM media) won’t be able to execute any malware upon mounting.

It also immunizes each system partition with a specially-crafted autorun.inf file.

The USB immunizer is available in English, Spanish, Portuguese, Arabic, Thai, Vietnamese, Polish, Farsi, German, French, and Romanian.

The software reads the current location of the user in the Region and Language settings and automatically loads the appropriate language file.

Do note that the Bitdefender antivirus for flash drives is not a standalone program. It comes incorporated in the complete antivirus package.



Bitdefender is a big name in the antivirus business, so it’s the best choice for protecting USB flash drives.

$23.99/year Visit website

Read our full Bitdefender review

get Panda USB Vaccine

The Panda USB Vaccine is a great utility that disables the Autorun feature from USB drives, preventing malware from infecting your PC.

When this software is applied on the USB drive, it will permanently block the autorun.inf file and it will prevent it from being read, created, deleted, and modified.

If you want to encrypt a USB flash drive on Windows 10, check out this article for the best tools to do that.

In this manner, Windows won’t be able to automatically execute any malicious file that might be stored on the flash drive.

You can then use your USB flash drive in a normal way to copy, move, or delete files.

The software works great on FAT and FAT32 USB drives. As a quick reminder, the USB drives that have already been vaccinated can only be reversed to a previous state through formatting.

Users can also operate the software via the command line. No less important, Panda USB Vaccine it’s part of the complete Panda antivirus package.

Therefore, we can only recommend downloading Panda antivirus which will double your USB-health security.



Stop worrying about USB flash drive infections when you use this antivirus. Claim the best Panda deal right away!

$29.49/year Vist website

get ClevX DriveSecurity

DriveSecurity is a powerful antivirus solution dedicated to users who often transfer various files, such as pictures, music, videos via USB drives.

The tool nips malware in the bud, removing it before you transfer any infected files to your drive. In this manner, your USB flash drive is always malware-free.

DriveSecurity detects a wide range of threats, including viruses, rootkits, worms, and spyware.

ClevX DriveSecurity USB antivirus key features:

  • Works with any USB drive
  • Automatic scanning and virus removal
  • No host installation required
  • Encrypted secure drives companion

Download ClevX DriveSecurity now

try out USB Disk Security

This program detects any virus before it infects your memory stick and then your whole system. By their very own nature, flash drives are prone to infections.

Oftentimes, users connect them to various computers and this increases the high risk of getting infected.

Don’t expose yourself to unnecessary risks. Find out why Windows Defender is a great malware barrier!

Once you install it, the USB Disk Security will automatically run whenever a flash drive is inserted into your machine, checking for infections.

USB Disk Security also features a USB scan tool and various repair options. Unfortunately, these features are not available in the trial version.

USB Disk Security delivers a high level of protection against any malicious programs.

It protects your PC against data theft and accidental disclosure of confidential information, preventing unauthorized persons from stealing your data.

The tool is also compatible with other antivirus software, and won’t slow down your computer.

When you minimize it, the USB Disk Security will run silently in the task tray.

The limitations of the trial version are a bit disappointing. The program is very efficient at scanning inserted flash drives and we really think it’s worth checking it out.

Download USB Disk Security now

This list features 4 of the best antivirus solutions for USB drives. All these programs are lightweight, automatic, and compatible with fully-fledged antivirus software.

They can be used whenever you’re looking for:

  • USB antivirus – USB flash drives are supposed to be virus-free, so make sure things remain the same even after months of usage.
  • Bootable antivirus USB – Bootable antivirus programs let you create a special flash drive from a working PC and later use it to scan the hard drive even without starting Windows.
  • USB antivirus scanner – When your wish is to scan your USB flash drives for any malware, these great antivirus solutions with USB scanner can help you out.
  • Run antivirus from USB – Booting your PC from a USB drive containing an antivirus often does wonders, so don’t hesitate to pick one of our previously mentioned antivirus solutions.

FAQ: Learn more about antivirus software solutions for USB flash drives

  • Do you really need antivirus software for USB?

Hackers, exploiters, and eavesdroppers have found new ways to use USB flash drives to infect PCs. That’s why using the best antivirus software tools for USB is mandatory.

  • What is the best USB antivirus?

If looking for the best USB antivirus, we can only suggest you try out Bitdefender USB Immunizer. Do note that it’s part of the Bitdefender antivirus package.

  • Do I need another antivirus if I have Windows Defender?

Windows Defender is indeed a decent choice. However, it falls quite short when it comes to real-time protection and USB flash drive safety.

Editor’s Note: This post was originally published in November 2019 and has been since revamped and updated in June 2020 for freshness, accuracy, and comprehensiveness.